A synthetic, CB1 agonist
Arachidonyl-2'-chloroethylamide (ACEA) is a synthetic agonist of the cannabinoid receptor 1 (CB1R). ACEA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the cannabinoid receptor 2 (CB2R) (Ki = 1.4 nM for CB1R; Ki = 3100 nM for CB2R).
|Molar mass||365.99 g·mol−1|
|Solubility in other solvents||soluble in ethanol, chloroform, THF and DMSO|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|Publication number||EP2733205 A1|
|Publication date||May 21, 2014|
|Filing date||Nov 20, 2012|
|Priority date||Nov 20, 2012|
|Inventors||Ismael Galve-Roperh, 3 More »|
|Applicant||Centro De Investigacíon Biomédica En Red De Enfermedades Neurodegenerativas Ciberned, 1 More »|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (10), Non-Patent Citations (73), Referenced by (1), Classifications (11), Legal Events (10)|
|External Links: Espacenet, EP Register|
EP 2733205 A1 Other Cannabis US Patents
Arachidonyl-2'-chloroethylamide (ACEA) Cannabis Science & Research
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2002 - Study ~ Revisiting CB1 Receptor as Drug Target in Human Melanoma.
2002 - Study ~ The cannabinoids R(-)-7-hydroxy-delta-6-tetra-hydrocannabinol-dimethylheptyl (HU-210), 2-O-arachidonoylglycerylether (HU-310) and arachidonyl-2-chloroethylamide (ACEA) increase isoflurane provoked sleep duration by activation of cannabinoids 1 (CB1)-receptors in mice.